Applied Maths Seminar: Osborne -- Multiscale modelling of multicellular biological systems

James Osborne (The University of Melbourne) will be visiting us for a day, and will give
a talk on Friday 19th September at 12pm in Carslaw 173 (note unusual day, time, room).  

Title: Multiscale modelling of multicellular biological systems 

Abstract: The coordinated behaviour of populations of cells plays a central role in
tissue growth and renewal.  Cells react to their microenvironment by modulating
processes such as movement, growth and proliferation, and signalling.  Alongside
experimental studies, computational models offer a useful means by which to investigate
these processes.  To this end a variety of cell-based modelling approaches have been
developed, ranging from lattice-based cellular automata to lattice-free models that
treat cells as point-like particles or extended shapes.  However, it remains unclear how
these approaches compare when applied to the same biological problem, and what
differences in behaviour are due to different model assumptions and abstractions.  In
this talk, we present a series of studies which demonstrate how modelling frameworks and
parameter choice influence simulation output and study outcome.